Rho/Rho-kinase mediated signaling in physiology and pathophysiology

被引：297

作者：

Wettschureck, N ^{[1
]}

Offermanns, S ^{[1
]}

机构：

[1] Univ Heidelberg, Inst Pharmacol, D-69120 Heidelberg, Germany

来源：

JOURNAL OF MOLECULAR MEDICINE-JMM | 2002年 / 80卷 / 10期

关键词：

Rho; Rho kinase; myosin light-chain phosphorylation; fasudil; Y-27632;

D O I：

10.1007/s00109-002-0370-2

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The small GTPase Rho is implicated in many cellular functions such as cell adhesion, cell motility and migration, growth control, cell contraction, and cytokinesis. One of its main effectors, Rho-kinase, appears to play a key role in the regulation of force and velocity of actomyosin crossbridging in smooth muscle and nonmuscle cells by inhibiting myosin phosphatase-mediated dephosphorylation of the regulatory chain of myosin II. Abnormal activation of the Rho/Rho-kinase pathway has been shown to play a role in diseases such as hypertension and bronchial asthma. This review summarizes the current knowledge on the physiological and pathophysiological function of the Rho/Rho-kinase mediated pathway in various tissues with a focus on its possible role as a target for therapeutic interventions.

引用

收藏

页码：629 / 638

页数：10

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