Monosodium [1-hydroxy-2-(1H-imidazol-3-ium-4-yl)ethane-1,1-diyl]-bis(phosphonate) tetrahydrate (monosodium isozoledronate)

被引：14

作者：

Gossman, WL ^{[1
]}

Wilson, SR ^{[1
]}

Oldfield, E ^{[1
]}

机构：

[1] Univ Illinois, Dept Chem, Urbana, IL 61801 USA

来源：

ACTA CRYSTALLOGRAPHICA SECTION C-CRYSTAL STRUCTURE COMMUNICATIONS | 2002年 / 58卷 / 12期

关键词：

D O I：

10.1107/S0108270102019522

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The title compound, Na+.C5H9N2O7P2-.4H(2)O, is an isomer of zoledronate, a potent bone antiresorptive bisphosphonate drug having significant activity against several parasitic protozoa. The crystal structure of isozoledronate consists of bisphosphonate dimers coordinated by two Na+ ions. The dimers are held together through an extensive hydrogen-bonding network. The crystals exhibit non-merohedral twinning that roughly superimposes the a and b axes, and inverts the c axis.

引用

页码：M599 / M600

页数：2

共 7 条

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