Organization of supercoil domains and their reorganization by transcription

被引:98
作者
Deng, S [1 ]
Stein, RA [1 ]
Higgins, NP [1 ]
机构
[1] Univ Alabama Birmingham, Dept Biochem & Mol Genet, Birmingham, AL 35294 USA
关键词
D O I
10.1111/j.1365-2958.2005.04796.x
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
During a normal cell cycle, chromosomes are exposed to many biochemical reactions that require specific types of DNA movement. Separation forces move replicated chromosomes into separate sister cell compartments during cell division, and the contemporaneous acts of DNA replication, RNA transcription and cotranscriptional translation of membrane proteins cause specific regions of DNA to twist, writhe and expand or contract. Recent experiments indicate that a dynamic and stochastic mechanism creates supercoil DNA domains soon after DNA replication. Domain structure is subsequently reorganized by RNA transcription. Examples of transcription-dependent chromosome remodelling are also emerging from eukaryotic cell systems.
引用
收藏
页码:1511 / 1521
页数:11
相关论文
共 112 条
  • [1] Genome-scale analysis of the uses of the Escherichia coli genome:: Model-driven analysis of heterogeneous data sets
    Allen, TE
    Herrgård, MJ
    Liu, MZ
    Qiu, Y
    Glasner, JD
    Blattner, FR
    Palsson, BO
    [J]. JOURNAL OF BACTERIOLOGY, 2003, 185 (21) : 6392 - 6399
  • [2] Artsimovitch Irina, 2005, P311
  • [3] FtsK is a DNA motor protein that activates chromosome dimer resolution by switching the catalytic state of the XerC and XerD recombinases
    Aussel, L
    Barre, FX
    Aroyo, M
    Stasiak, A
    Stasiak, AZ
    Sherratt, D
    [J]. CELL, 2002, 108 (02) : 195 - 205
  • [4] Growth phase-dependent variation in protein composition of the Escherichia coli nucleoid
    Azam, TA
    Iwata, A
    Nishimura, A
    Ueda, S
    Ishihama, A
    [J]. JOURNAL OF BACTERIOLOGY, 1999, 181 (20) : 6361 - 6370
  • [5] Bacterial persistence as a phenotypic switch
    Balaban, NQ
    Merrin, J
    Chait, R
    Kowalik, L
    Leibler, S
    [J]. SCIENCE, 2004, 305 (5690) : 1622 - 1625
  • [6] BAUER WR, 1980, SCI AM, V243, P118
  • [7] Global analysis of mRNA decay and abundance in Escherichia coli at single-gene resolution using two-color fluorescent DNA microarrays
    Bernstein, JA
    Khodursky, AB
    Lin, PH
    Lin-Chao, S
    Cohen, SN
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (15) : 9697 - 9702
  • [8] How the mouse got its spots
    Blewitt, ME
    Chong, S
    Whitelaw, E
    [J]. TRENDS IN GENETICS, 2004, 20 (11) : 550 - 554
  • [9] USE OF SITE-SPECIFIC RECOMBINATION AS A PROBE OF DNA-STRUCTURE AND METABOLISM INVIVO
    BLISKA, JB
    COZZARELLI, NR
    [J]. JOURNAL OF MOLECULAR BIOLOGY, 1987, 194 (02) : 205 - 218
  • [10] CORALLINE SHAPE OF THE BACTERIAL NUCLEOID AFTER CRYOFIXATION
    BOHRMANN, B
    VILLIGER, W
    JOHANSEN, R
    KELLENBERGER, E
    [J]. JOURNAL OF BACTERIOLOGY, 1991, 173 (10) : 3149 - 3158