Peroral route:: An opportunity for protein and peptide drug delivery

The challenges encountered in the peroral route for protein and peptide drug delivery were discussed. The chemical approaches which enhanced PP drug delivery included prodrug development, pegylation and small molecular complex-forming agents. Approaches based on modulation of gastrointestinal absorption barrier properties were useful provided their toxic manifestations were overcome. The approaches were effectively combined with other strategies for providing maximum protection from degradation and achieving drug-delivery at the preferred site of absorption.