Development and function of bombesin-like peptides and their receptors

被引：139

作者：

Ohki-Hamazaki, H ^{[1
]}

Iwabuchi, M

Maekawa, F

机构：

[1] Tokyo Med & Dent Univ, Sch Biomed Sci, Lab Mol Neurosci, Bunkyo Ku, Tokyo 1138519, Japan

[2] Tokyo Med & Dent Univ, Inst Med Res, Bunkyo Ku, Tokyo 1138519, Japan

[3] Jichi Med Sch, Dept Physiol, Div Integrat Physiol, Kawachi, Tochigi 3290498, Japan

来源：

INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY | 2005年 / 49卷 / 2-3期

关键词：

gastrin-releasing peptide; neuromedin B; bombesin-like peptide receptor subtype-3 (BRS-3);

D O I：

10.1387/ijdb.041954ho

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Amphibian bombesin and its related peptides consist a family of neuropeptides in many vertebrate species. Bombesin and two major bombesin-like peptide in mammals, gastrin-releasing peptide (GRP) and neuromedin B (NMB), have been shown to elicit various physiological effects. These include inhibition of feeding, smooth muscle contraction, exocrine and endocrine secretions, thermoregulation, blood pressure and sucrose regulations and cell growth. Receptors for GRP and NMB (GRP-R and NMB-R), as well as third subtype of bombesin-like peptide receptor (BRS-3) have been cloned. These receptors are G-protein-coupled receptors and are expressed in various brain regions and in the digestive tract. In this paper, we will summarize studies on these peptides and their receptors, with special reference to research using gene-knockout mice. These studies clearly demonstrated the role of three receptors in vivo and in vitro. We will also discuss the phylogeny of these receptors.

引用

页码：293 / 300

页数：8