Molecular regulation of the life cycle of African trypanosomes

被引：60

作者：

Matthews, KR ^{[1
]}

Ellis, JR ^{[1
]}

Paterou, A ^{[1
]}

机构：

[1] Univ Manchester, Sch Biol Sci, Manchester M13 9PT, Lancs, England

来源：

TRENDS IN PARASITOLOGY | 2004年 / 20卷 / 01期

基金：

英国惠康基金; 英国生物技术与生命科学研究理事会;

关键词：

D O I：

10.1016/j.pt.2003.10.016

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Preventing the transmission of African trypanosomes between mammalian hosts has been one of the most effective mechanisms to date for the control of these important parasites. Hence, understanding the mechanisms through which they control their life cycle in molecular terms could provide valuable strategies for restricting the impact of sleeping sickness. Over the past two to three years, the study of the molecular cell biology of trypanosome life cycle progression has made considerable advances. Here, these advances are placed in the context of the biology of the parasite, to provide an integrated overview of developmental events in Trypanosoma brucei.

引用

页码：40 / 47

页数：8

共 67 条

[21] Life-cycle differentiation in Trypanosoma brucei:: molecules and mutants [J].

Hendriks, E ;

van Deursen, FJ ;

Wilson, J ;

Sarkar, M ;

Timms, M ;

Matthews, KR .

BIOCHEMICAL SOCIETY TRANSACTIONS, 2000, 28 :531-536

[22] A novel CCCH protein which modulates differentiation of Trypanosoma brucei to its procyclic form [J].

Hendriks, EF ;

Robinson, DR ;

Hinkins, M ;

Matthews, KR .

EMBO JOURNAL, 2001, 20 (23) :6700-6711

[23] CAP5.5, a life-cycle-regulated, cytoskeleton-associated protein is a member of a novel family of calpain-related proteins in Trypanosoma brucei [J].

Hertz-Fowler, C ;

Ersfeld, K ;

Gull, K .

MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 2001, 116 (01) :25-34

[24] Trypanosoma brucei expression-site-associated-gene-8 protein interacts with a Pumilio family protein [J].

Hoek, M ;

Zanders, T ;

Cross, GAM .

MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 2002, 120 (02) :269-283

[25] Mechanisms of developmental regulation in Trypanosoma brucei: A polypyrimidine tract in the 3'-untranslated region of a surface protein mRNA affects RNA abundance and translation [J].

Hotz, HR ;

Hartmann, C ;

Huober, K ;

Hug, M ;

Clayton, C .

NUCLEIC ACIDS RESEARCH, 1997, 25 (15) :3017-3025

[26] DIFFERENTIAL ACCUMULATION OF A PROTEIN-KINASE HOMOLOG IN TRYPANOSOMA-BRUCEI [J].

HUA, SB ;

WANG, CC .

JOURNAL OF CELLULAR BIOCHEMISTRY, 1994, 54 (01) :20-31

[27]

Hua SB, 1997, J BIOL CHEM, V272, P10797, DOI 10.1074/jbc.272.16.10797

[28] Expression and function of the Trypanosoma brucei major surface protease (GP63) genes [J].

LaCount, DJ ;

Gruszynski, AE ;

Grandgenett, PM ;

Bangs, JD ;

Donelson, JE .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (27) :24658-24664

[29]

Lai WS, 1999, MOL CELL BIOL, V19, P4311

[30] Differentiation of Trypanosoma brucei may be stage non-specific and does not require progression of cell cycle [J].

Li, Y ;

Li, ZY ;

Wang, CC .

MOLECULAR MICROBIOLOGY, 2003, 49 (01) :251-265

← 1 2 3 4 5 6 7 →