Regulation of apoptosis by vasoactive peptides

被引:57
作者
Filippatos, GS
Gangopadhyay, N
Lalude, O
Parameswaran, N
Said, SI
Spielman, W
Uhal, BD
机构
[1] Michigan State Univ, Dept Physiol, E Lansing, MI 48824 USA
[2] Evangelismos Gen Hosp, Div Cardiol 2, GR-11526 Athens, Greece
[3] Case Western Reserve Univ, Metrohlth Med Ctr, Div Cardiol, Cleveland, OH 44106 USA
[4] Univ Med Ctr, Dept Med, Stony Brook, NY 11794 USA
[5] Vet Affairs Med Ctr, Northport, NY 11772 USA
关键词
programmed cell death; blood pressure; pulmonary pathophysiology; hypertension; lung fibrosis;
D O I
10.1152/ajplung.2001.281.4.L749
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
Although originally discovered because of their ability to affect hemodynamics, vasoactive peptides have been found to function in a variety of capacities including neurotransmission, endocrine functions, and the regulation of cell proliferation. A growing body of evidence describes the ability of vasoactive peptides to regulate cell death by apoptosis in either a positive or negative fashion depending on the peptide and the type of target cell. The available evidence to date is strongest for the peptides endothelin, angiotensin II, vasoactive intestinal peptide, atrial natriuretic peptide, and adrenomedullin. Each of these peptides is discussed, with specific regard to apoptosis, in terms of regulatory activity, target cell specificity, and potential role in pulmonary physiology.
引用
收藏
页码:L749 / L761
页数:13
相关论文
共 133 条
  • [91] MOLECULAR-CLONING AND BIOLOGICAL-ACTIVITIES OF RAT ADRENOMEDULLIN, A HYPOTENSIVE PEPTIDE
    SAKATA, J
    SHIMOKUBO, T
    KITAMURA, K
    NAKAMURA, S
    KANGAWA, K
    MATSUO, H
    ETO, T
    [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1993, 195 (02) : 921 - 927
  • [92] Adrenomedullin and the control of fluid and electrolyte homeostasis
    Samson, WK
    [J]. ANNUAL REVIEW OF PHYSIOLOGY, 1999, 61 : 363 - 389
  • [93] Proadrenomedullin-derived peptides
    Samson, WK
    [J]. FRONTIERS IN NEUROENDOCRINOLOGY, 1998, 19 (02) : 100 - 127
  • [94] Adrenomedullin and nitric oxide inhibit human endothelial cell apoptosis via a cyclic GMP-independent mechanism
    Sata, M
    Kakoki, M
    Nagata, D
    Nishimatsu, H
    Suzuki, E
    Aoyagi, T
    Sugiura, S
    Kojima, H
    Nagano, T
    Kangawa, K
    Matsuo, H
    Omata, M
    Nagai, R
    Hirata, Y
    [J]. HYPERTENSION, 2000, 36 (01) : 83 - 88
  • [95] Apoptosis in aorta of deoxycorticosterone acetate salt hypertensive rats: effect of endothelin receptor antagonism
    Sharifi, AM
    Schiffrin, EL
    [J]. JOURNAL OF HYPERTENSION, 1997, 15 (12) : 1441 - 1448
  • [96] Endothelin receptor antagonist SB209670 decreases lung allograft apoptosis and improves lung graft function after prolonged ischemia
    Shaw, MJ
    Shennib, H
    Tayara, L
    Ohlstein, T
    Giaid, A
    [J]. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 2000, 36 : S209 - S211
  • [97] Induction of Max by adrenomedullin and calcitonin gene-related peptide antagonizes endothelial apoptosis
    Shichiri, M
    Kato, H
    Doi, M
    Marumo, F
    Hirata, Y
    [J]. MOLECULAR ENDOCRINOLOGY, 1999, 13 (08) : 1353 - 1363
  • [98] Endothelin-1 inhibits apoptosis of vascular smooth muscle cells induced by nitric oxide and serum deprivation via MAP kinase pathway
    Shichiri, M
    Yokokura, M
    Marumo, F
    Hirata, Y
    [J]. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2000, 20 (04) : 989 - 997
  • [99] ENDOTHELIN-1 IS AN AUTOCRINE PARACRINE GROWTH-FACTOR FOR HUMAN CANCER CELL-LINES
    SHICHIRI, M
    HIRATA, Y
    NAKAJIMA, T
    ANDO, K
    IMAI, T
    YANAGISAWA, M
    MASAKI, T
    MARUMO, F
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 1991, 87 (05) : 1867 - 1871
  • [100] Endothelin-1 is a potent survival factor for c-Myc-dependent apoptosis
    Shichiri, M
    Sedivy, JM
    Marumo, F
    Hirata, Y
    [J]. MOLECULAR ENDOCRINOLOGY, 1998, 12 (02) : 172 - 180