IFIH1 gene polymorphisms in type 1 diabetes: Genetic association analysis and genotype-phenotype correlation in the Belgian population

被引：17

作者：

Aminkeng, Folefac ^{[1
]}

Van Autreve, Jan E. ^{[1
]}

Weets, Ilse ^{[1
]}

Quartier, Erik ^{[1
]}

Van Schravendijk, Chris ^{[1
]}

Gorus, Frans K. ^{[1
]}

Van der Auwera, Bart J. ^{[1
]}

机构：

[1] Vrije Univ Brussel, Diabet Res Ctr, Fac Med & Pharm, Brussels, Belgium

来源：

HUMAN IMMUNOLOGY | 2009年 / 70卷 / 09期

关键词：

Type; 1; diabetes; Genetic association; Interferon-induced helicase; IFIH1; Autoimmune disease; GENOME-WIDE ASSOCIATION; IFIH1-GCA-KCNH7; LOCUS; MULTIPLE-SCLEROSIS; A946T POLYMORPHISM; GRAVES-DISEASE; SUSCEPTIBILITY; RISK; AGE;

D O I：

10.1016/j.humimm.2009.06.013

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

The evaluation of susceptibility loci in a registry-based setting could be an important addition to the current predictive and screening models in T1D. Therefore, the aim of this Study was to evaluate the importance of one of these loci, IFIH1. T1D patients (n = 1981), control subjects (n = 2092) and 430 families were genotyped for HLA-DQ and IFIH1 nsSNP rsl 990760 (Ala946Thr). In the association analysis, the allelic frequencies, A (62.4% vs. 61.3%) and G (37.6% vs. 38.7%) were similar in cases and controls (chi(2) = 0.98, p = 0.32), the genotypic frequencies reveals a weak association with T1D (chi(2) = 6.79, p = 0.03), no significant transmission distortions in families (%T; A = 51.4%, G = 48.0 %, chi(2) = 1.76, p = 0.19) and no interaction with HLA-DQ-linked risk. no genotype-phenotype correlation was observed. In conclusion, IFIH1 has no important role in Furthermore, T1D risk assessment in a registry-based Belgian Population. (C) 2009 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.

引用

页码：706 / 710

页数：5

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