Characterization of venlafaxine hydrochloride and compatibility studies with pharmaceutical excipients

被引：46

作者：

Bernardi, L. S. ^{[1
]}

Oliveira, P. R. ^{[1
]}

Murakami, F. S. ^{[1
]}

Silva, M. A. S. ^{[1
]}

Borgmann, S. H. M. ^{[1
]}

Cardoso, S. G. ^{[1
]}

机构：

[1] Univ Fed Santa Catarina, Lab Controle Qualidade, BR-88040900 Florianopolis, SC, Brazil

来源：

JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY | 2009年 / 97卷 / 02期

关键词：

Venlafaxine hydrochloride; Solid-state characterization; Compatibility studies; SOLID DOSAGE FORMS; THERMAL-ANALYSIS; BINARY-MIXTURES; DECOMPOSITION; AZT;

D O I：

10.1007/s10973-009-0282-2

中图分类号：

O414.1 [热力学];

学科分类号：

070201 [理论物理];

摘要：

The thermal analytical study of venlafaxine hydrochloride, a third generation antidepressant, was investigated using thermogravimetry (TG) and differential scanning calorimetry (DSC). The DSC curves have shown a sharp endothermic event at 211 A degrees C and TG demonstrated a single stage of mass loss between 254 and 283 A degrees C. Solid-state characterization was carried out by DRIFT, SEM, and XRPD demonstrating the drug physicochemical properties including crystallinity. Drug-excipient compatibility studies investigated by DSC have shown a possible physical interaction of the drug with magnesium stearate, microcrystalline cellulose and starch. Nevertheless, these results where not confirmed by DRIFT and SEM analyses.

引用

页码：729 / 733

页数：5

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