Signaling networks in hepatic oval cell activation

被引：70

作者：

Erker, Laura ^{[1
]}

Grompe, Markus ^{[1
,2
]}

机构：

[1] Oregon Hlth & Sci Univ, Oregon Stem Cell Ctr, Portland, OR 97239 USA

[2] Oregon Hlth & Sci Univ, Dept Mol & Med Genet, Portland, OR 97239 USA

来源：

STEM CELL RESEARCH | 2008年 / 1卷 / 02期

关键词：

D O I：

10.1016/j.scr.2008.01.002

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Oval cells are hypothesized to be the progeny of intrahepatic stem cells, also referred to as adult liver stem cells. The mechanisms by which these cells are activated to proliferate and differentiate during liver regeneration is important for the development of new therapies to treat liver disease. Oval cell activation is the first step in progenitor-dependent liver regeneration in response to certain types of injury. This review describes what is currently known about the factors involved in oval cell activation, proliferation, migration, and differentiation. (C) 2008 Elsevier B.V. All rights reserved.

引用

页码：90 / 102

页数：13

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