Scalable Enantioseparation of Amino Acid Derivatives Using Continuous Liquid-Liquid Extraction in a Cascade of Centrifugal Contactor Separators

被引：68

作者：

Schuur, Boelo ^{[2
]}

Hallet, Andrew J. ^{[1
]}

Winkelman, Jozef G. M. ^{[2
]}

de Vries, Johannes G. ^{[1
,3
]}

Heeres, Hero J. ^{[2
]}

机构：

[1] DSM Pharmaceut Prod, Innovat Synth & Catalysis, NL-6160 MD Geleen, Netherlands

[2] Univ Groningen, Dept Chem Engn, NL-9747 AG Groningen, Netherlands

[3] Univ Groningen, Stratingh Inst Chem, NL-9747 AG Groningen, Netherlands

来源：

ORGANIC PROCESS RESEARCH & DEVELOPMENT | 2009年 / 13卷 / 05期

关键词：

CHIRAL SEPARATION; ENANTIOSELECTIVE EXTRACTION; REACTIVE EXTRACTION; OPTICAL RESOLUTION; CO-EXTRACTANTS; ENANTIOMERS; CHROMATOGRAPHY; EQUILIBRIUM; ALCOHOLS; RECOGNITION;

D O I：

10.1021/op900152e

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Using a cascade of six centrifugal contactor separators in a countercurrent liquid-liquid extraction mode allowed the separation of one of the enantiomers of 3,5-dinitrobenzoyl-leucine in 55% yield and 98% ee using a catalytic amount of a chiral host compound based on a cinchona alkaloid, This method allows the preparation of kilograms of enantiopure material in table-top-sized equipment that can be operated in a fume cupboard. The methodology can be easily scaled up to ton amounts as large-volume centrifugal contactor separators are commercially available as well.

引用

页码：911 / 914

页数：4

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