Strategies in optical resolution:: a practical guide

被引：119

作者：

Faigl, Ferenc ^{[1
]}

Fogassy, Elemer ^{[1
]}

Nogradi, Mihaly ^{[1
]}

Palovics, Emese ^{[2
]}

Schindler, Jozsef ^{[2
]}

机构：

[1] Univ Technol & Econ, Dept Organ Chem & Technol, H-1521 Budapest, Hungary

[2] Univ Technol & Econ, Organ Chem Technol Res Grp, H-1521 Budapest, Hungary

来源：

TETRAHEDRON-ASYMMETRY | 2008年 / 19卷 / 05期

基金：

匈牙利科学研究基金会;

关键词：

D O I：

10.1016/j.tetasy.2008.02.004

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Despite the dramatic development of enantio selective synthesis and chromatographic separation methods, resolution still remains the most inexpensive and operationally simplest method for producing pure enantiomers on a large scale. No extreme conditions or expensive reagents are required and the expensive resolving agents can be eventually recovered. This review presents guidelines for selecting the optimal method for resolving a given racemate and is based mainly on the authors long experience in the resolution of industrially important molecules. Methods for predicting the efficiency of the resolution based on the analysis of physico-chemical properties of the reactants are also described. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：519 / 536

页数：18

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