RCSB Protein Data Bank: powerful new tools for exploring 3D structures of biological macromolecules for basic and applied research and education in fundamental biology, biomedicine, biotechnology, bioengineering and energy sciences

被引：1076

作者：

Burley, Stephen K. ^{[1
,2
,3
,4
,5
]}

Bhikadiya, Charmi ^{[1
,2
]}

Bi, Chunxiao ^{[4
]}

Bittrich, Sebastian ^{[4
]}

Chen, Li ^{[1
,2
]}

Crichlow, Gregg, V ^{[1
,2
]}

Christie, Cole H. ^{[4
]}

Dalenberg, Kenneth ^{[1
,2
]}

Di Costanzo, Luigi ^{[1
,2
,8
]}

Duarte, Jose M. ^{[4
]}

Dutta, Shuchismita ^{[1
,2
,3
]}

Feng, Zukang ^{[1
,2
]}

Ganesan, Sai ^{[6
]}

Goodsell, David S. ^{[1
,2
,7
]}

Ghosh, Sutapa ^{[1
,2
]}

Green, Rachel Kramer ^{[1
,2
]}

Guranovic, Vladimir ^{[1
,2
]}

Guzenko, Dmytro ^{[4
]}

Hudson, Brian P. ^{[1
,2
]}

Lawson, Catherine L. ^{[1
,2
]}

Liang, Yuhe ^{[1
,2
]}

Lowe, Robert ^{[1
,2
]}

Namkoong, Harry ^{[1
,2
]}

Peisach, Ezra ^{[1
,2
]}

Persikova, Irina ^{[1
,2
]}

Randle, Chris ^{[4
]}

Rose, Alexander ^{[4
]}

Rose, Yana ^{[4
]}

Sali, Andrej ^{[6
]}

Segura, Joan ^{[4
]}

Sekharan, Monica ^{[1
,2
]}

Shao, Chenghua ^{[1
,2
]}

Tao, Yi-Ping ^{[1
,2
]}

Voigt, Maria ^{[1
,2
]}

Westbrook, John D. ^{[1
,2
,3
]}

Young, Jasmine Y. ^{[1
,2
]}

Zardecki, Christine ^{[1
,2
]}

Zhuravleva, Marina ^{[1
,2
]}

机构：

[1] Rutgers State Univ, Res Collab Struct Bioinformat Prot Data Bank, Piscataway, NJ 08854 USA

[2] Rutgers State Univ, Inst Quantitat Biomed, Piscataway, NJ 08854 USA

[3] Rutgers State Univ, Canc Inst New Jersey, New Brunswick, NJ 08901 USA

[4] Univ Calif San Diego, San Diego Supercomp Ctr, Res Collab Struct Bioinformat Prot Data Bank, La Jolla, CA 92093 USA

[5] Rutgers State Univ, Dept Chem & Chem Biol, Piscataway, NJ 08854 USA

[6] Univ Calif San Francisco, Dept Biotherapeut Sci, Res Collab Struct Bioinformat Prot Data Bank, San Francisco, CA 94158 USA

[7] Scripps Res Inst, Ctr Computat Struct Biol, La Jolla, CA 92037 USA

[8] Univ Napoli Federico II, Dipartimento Agr, Portici, Campania, Italy

来源：

NUCLEIC ACIDS RESEARCH | 2021年 / 49卷 / D1期

基金：

美国国家科学基金会;

关键词：

VALIDATION; WWPDB; WIDE;

D O I：

10.1093/nar/gkaa1038

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

The Research Collaboratory for Structural Bioinformatics Protein Data Bank (RCSB PDB), the US data center for the global PDB archive and a founding member of the Worldwide Protein Data Bank partnership, serves tens of thousands of data depositors in the Americas and Oceania and makes 3D macromolecular structure data available at no charge and without restrictions to millions of RCSB.org users around the world, including >660 000 educators, students and members of the curious public using PDB101.RCSB.org. PDB data depositors include structural biologists using macromolecular crystallography, nuclear magnetic resonance spectroscopy, 3D electronmicroscopy andmicro-electron diffraction. PDB data consumers accessing our web portals include researchers, educators and students studying fundamental biology, biomedicine, biotechnology, bioengineering and energy sciences. During the past 2 years, the research-focused RCSB PDB web portal (RCSB.org) has undergone a complete redesign, enabling improved searching with full Boolean operator logic and more facile access to PDB data integrated with >40 external biodata resources. New features and resources are described in detail using examples that showcase recently released structures of SARS-CoV-2 proteins and host cell proteins relevant to understanding and addressing the COVID-19 global pandemic.

引用

页码：D437 / D451

页数：15

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