SCOP2 prototype: a new approach to protein structure mining

被引：204

作者：

Andreeva, Antonina ^{[1
]}

Howorth, Dave ^{[1
]}

Chothia, Cyrus ^{[1
]}

Kulesha, Eugene ^{[2
]}

Murzin, Alexey G. ^{[1
]}

机构：

[1] MRC, Mol Biol Lab, Cambridge CB2 0QH, England

[2] European Bioinformat Inst, Cambridge CB10 1SD, England

来源：

NUCLEIC ACIDS RESEARCH | 2014年 / 42卷 / D1期

基金：

英国生物技术与生命科学研究理事会; 英国医学研究理事会;

关键词：

CLASSIFICATION; EVOLUTION; DATABASE; CONVERGENCE; PRINCIPLES; FOLD;

D O I：

10.1093/nar/gkt1242

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We present a prototype of a new structural classification of proteins, SCOP2 (http://scop2.mrc-lmb.cam.ac.uk/), that we have developed recently. SCOP2 is a successor to the Structural Classification of Proteins (SCOP, http://scop.mrc-lmb.cam.ac.uk/scop/) database. Similarly to SCOP, the main focus of SCOP2 is to organize structurally characterized proteins according to their structural and evolutionary relationships. SCOP2 was designed to provide a more advanced framework for protein structure annotation and classification. It defines a new approach to the classification of proteins that is essentially different from SCOP, but retains its best features. The SCOP2 classification is described in terms of a directed acyclic graph in which nodes form a complex network of many-to-many relationships and are represented by a region of protein structure and sequence. The new classification project is expected to ensure new advances in the field and open new areas of research.

引用

页码：D310 / D314

页数：5

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