Regulatory roles of natural antisense transcripts

被引：575

作者：

Faghihi, Mohammad Ali ^{[1
]}

Wahlestedt, Claes ^{[1
]}

机构：

[1] Scripps Res Inst, MIND, Jupiter, FL 33458 USA

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2009年 / 10卷 / 09期

关键词：

SMALL INTERFERING RNAS; SINGLE-STRANDED-DNA; NONCODING RNA; GENE-EXPRESSION; MESSENGER-RNA; INTERGENIC TRANSCRIPTION; ENDOGENOUS SIRNAS; MAMMALIAN-CELLS; HUMAN PROMOTERS; MOUSE OOCYTES;

D O I：

10.1038/nrm2738

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Mammalian genomes encode numerous natural antisense transcripts, but the function of these transcripts is not well understood. Functional validation studies indicate that antisense transcripts are not a uniform group of regulatory RNAs but instead belong to multiple categories with some common features. Recent evidence indicates that antisense transcripts are frequently functional and use diverse transcriptional and post-transcriptional gene regulatory mechanisms to carry out a wide variety of biological roles.

引用

收藏

页码：637 / 643

页数：7

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