The use and analysis of microarray data

被引：309

作者：

Butte, A

机构：

[1] Childrens Hosp, Informat Program, Boston, MA 02115 USA

[2] Childrens Hosp, Div Endocrinol, Boston, MA 02115 USA

来源：

NATURE REVIEWS DRUG DISCOVERY | 2002年 / 1卷 / 12期

关键词：

D O I：

10.1038/nrd961

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Functional genomics is the study of gene function through the parallel expression measurements of genomes, most commonly using the technologies of microarrays and serial analysis of gene expression. Microarray usage in drug discovery is expanding, and its applications include basic research and target discovery, biomarker determination, pharmacology, toxicogenomics, target selectivity, development of prognostic tests and disease-subclass determination. This article reviews the different ways to analyse large sets of microarray data, including the questions that can be asked and the challenges in interpreting the measurements.

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收藏

页码：951 / 960

页数：10

相关论文

共 53 条

[41]

Szallasi Z, 1998, Pac Symp Biocomput, P66

[42] Interpreting patterns of gene expression with self-organizing maps: Methods and application to hematopoietic differentiation [J].

Tamayo, P ;

Slonim, D ;

Mesirov, J ;

Zhu, Q ;

Kitareewan, S ;

Dmitrovsky, E ;

Lander, ES ;

Golub, TR .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (06) :2907-2912

[43] Analysis of gene expression data using self-organizing maps [J].

Törönen, P ;

Kolehmainen, M ;

Wong, C ;

Castrén, E .

FEBS LETTERS, 1999, 451 (02) :142-146

[44] Issues in cDNA microarray analysis: quality filtering, channel normalization, models of variations and assessment of gene effects [J].

Tseng, GC ;

Oh, MK ;

Rohlin, L ;

Liao, JC ;

Wong, WH .

NUCLEIC ACIDS RESEARCH, 2001, 29 (12) :2549-2557

[45] Significance analysis of microarrays applied to the ionizing radiation response [J].

Tusher, VG ;

Tibshirani, R ;

Chu, G .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (09) :5116-5121

[46] SERIAL ANALYSIS OF GENE-EXPRESSION [J].

VELCULESCU, VE ;

ZHANG, L ;

VOGELSTEIN, B ;

KINZLER, KW .

SCIENCE, 1995, 270 (5235) :484-487

[47] Reproducibility of alternative probe synthesis approaches for gene expression profiling with arrays [J].

Vernon, SD ;

Unger, ER ;

Rajeevan, M ;

Dimulescu, IM ;

Nisenbaum, R ;

Campbell, CE .

JOURNAL OF MOLECULAR DIAGNOSTICS, 2000, 2 (03) :124-127

[48] Large-scale temporal gene expression mapping of central nervous system development [J].

Wen, XL ;

Fuhrman, S ;

Michaels, GS ;

Carr, DB ;

Smith, S ;

Barker, JL ;

Somogyi, R .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (01) :334-339

[49]

Wu TD, 2001, J PATHOL, V195, P53, DOI 10.1002/1096-9896(200109)195:1<53::AID-PATH891>3.0.CO

[50]

2-H

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