Heat-shock proteins in infection-mediated inflammation-induced tumorigenesis

被引：35

作者：

Goldstein, Mark G. ^{[1
]}

Li, Zihai ^{[1
]}

机构：

[1] Univ Connecticut, Ctr Hlth, Ctr Immunotherapy Canc & Infect Dis, Farmington, CT 06030 USA

来源：

JOURNAL OF HEMATOLOGY & ONCOLOGY | 2009年 / 2卷

关键词：

NF-KAPPA-B; TUMOR-ASSOCIATED MACROPHAGES; INNATE IMMUNE-SYSTEM; HUMAN BREAST-CANCER; HELICOBACTER-PYLORI; DENDRITIC CELLS; NITRIC-OXIDE; CHEMOATTRACTANT PROTEIN-1; HEPATOCELLULAR-CARCINOMA; INDUCED CARCINOGENESIS;

D O I：

10.1186/1756-8722-2-5

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Inflammation is a necessary albeit insufficient component of tumorigenesis in some cancers. Infectious agents directly implicated in tumorigenesis have been shown to induce inflammation. This process involves both the innate and adaptive components of the immune system which contribute to tumor angiogenesis, tumor tolerance and metastatic properties of neoplasms. Recently, heat-shock proteins have been identified as mediators of this inflammatory process and thus may provide a link between infection-mediated inflammation and subsequent cancer development. In this review, the role of heat-shock proteins in infection-induced inflammation and carcinogenesis will be discussed.

引用

页数：10

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