Activity of voriconazole against corneal isolates of Scedosporium apiospermum

被引：38

作者：

Shah, KB ^{[1
]}

Wu, TG ^{[1
]}

Wilhelmus, KR ^{[1
]}

Jones, DB ^{[1
]}

机构：

[1] Baylor Coll Med, Dept Ophthalmol, Cullen Eye Inst, Sid W Richardson Ocular Microbiol Lab, Houston, TX 77030 USA

来源：

CORNEA | 2003年 / 22卷 / 01期

关键词：

fungal keratis; antifungal drugs; Scedosporium apiospermum;

D O I：

10.1097/00003226-200301000-00008

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Purpose. To determine the in vitro antifungal activity of voriconazole, a new triazole, compared with other polyene and imidazole antifungal agents against corneal isolates of Scedosporium apiospermum. Methods. Macro-broth dilution susceptibility testing was performed on five isolates of S. apiospermum obtained from patients with keratomycosis to determine the minimal inhibitory concentrations (MICs) for amphotericin B, natamycin, ketoconazole, itraconazole, and voriconazole. The use of oral voriconazole in the management of a patient with posttraumatic S. apiospermum keratitis is described. Results. S. apiospermum is generally resistant to commonly used topical ophthalmic antifungal agents. The MIC of voriconazole was 0.5 mug/mL, a concentration lower than that of other imidazoles. Conclusion. Voriconazole has promising activity against S. apiospermum and may prove useful in the management of fungal keratitis.

引用

页码：33 / 36

页数：4

共 24 条

[1]

ARTHUR S, 2001, ANTIMICROB AGENTS CH, V39, P2151

[2]

BEHRENSBAUMANN W, 1999, DEV OPHTHALMOL, V32, P37

[3] TREATMENT FAILURE IN A CASE OF FUNGAL KERATITIS CAUSED BY PSEUDALLESCHERIA-BOYDII [J].

BLOOM, PA ;

LAIDLAW, DAH ;

EASTY, DL ;

WARNOCK, DW .

BRITISH JOURNAL OF OPHTHALMOLOGY, 1992, 76 (06) :367-368

[4] In vitro activities of four novel triazoles against Scedosporium spp. [J].

Carrillo, AJ ;

Guarro, J .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2001, 45 (07) :2151-2153

[5] PREVALENCE OF FUNGAL CORNEAL ULCERS IN NORTHERN INDIA [J].

CHANDER, J ;

SHARMA, A .

INFECTION, 1994, 22 (03) :207-209

[6] Comparative in-vitro activity of voriconazole (UK-109,496) and six other antifungal agents against clinical isolates of Scedosporium prolificans and Scedosporium apiospermum [J].

Cuenca-Estrella, M ;

Ruiz-Díez, B ;

Martínez-Suárez, JV ;

Monzón, A ;

Rodríguez-Tudela, JL .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1999, 43 (01) :149-151

[7]

DHORDY K, 2000, B SOC BELGE OPHTALMO, V277, P53

[8] In vitro antifungal activities of voriconazole and reference agents as determined by NCCLS methods: Review of the literature [J].

Espinel-Ingroff, A ;

Boyle, K ;

Sheehan, DJ .

MYCOPATHOLOGIA, 2001, 150 (03) :101-115

[9] In vitro fungicidal activities of voriconazole, itraconazole, and amphotericin B against opportunistic moniliaceous and dematiaceous fungi [J].

Espinel-Ingroff, A .

JOURNAL OF CLINICAL MICROBIOLOGY, 2001, 39 (03) :954-958

[10] Acanthamoeba keratitis associated with fungal keratitis [J].

Froumis, NA ;

Mondino, BJ ;

Glasgow, BJ .

AMERICAN JOURNAL OF OPHTHALMOLOGY, 2001, 131 (04) :508-509

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