Does the antibacterial activity of silver nanoparticles depend on the shape of the nanoparticle?: A study of the gram-negative bacterium Escherichia coli

被引:3018
作者
Pal, Sukdeb
Tak, Yu Kyung
Song, Joon Myong [1 ]
机构
[1] Seoul Natl Univ, Res Inst Pharmaceut Sci, Seoul 151742, South Korea
[2] Seoul Natl Univ, Coll Pharm, Seoul 151742, South Korea
关键词
METAL; BIOCOMPATIBILITY; SPECTROSCOPY; NANOWIRES; IONS;
D O I
10.1128/AEM.02218-06
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
In this work we investigated the antibacterial properties of differently shaped silver nanoparticles against the gram-negative bacterium Escherichia coli, both in liquid systems and on agar plates. Energy-filtering transmission electron microscopy images revealed considerable changes in the cell membranes upon treatment, resulting in cell death. Truncated triangular silver nanoplates with a {111} lattice plane as the basal plane displayed the strongest biocidal action, compared with spherical and rod-shaped nanoparticles and with Ag+ (in the form of AgNO3). It is proposed that nanoscale size and the presence of a {111} plane combine to promote this biocidal property. To our knowledge, this is the first comparative study on the bactericidal properties of silver nanoparticles of different shapes, and our results demonstrate that silver nanoparticles undergo a shape-dependent interaction with the gram-negative organism E. coli.
引用
收藏
页码:1712 / 1720
页数:9
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