Fine mapping of the human renal oncocytoma-associated translocation (5;11)(q35;q13) breakpoint

被引：29

作者：

Sinke, RJ

Dijkhuizen, T

Janssen, B

Weghuis, DO

Merkx, G

vandenBerg, E

Schuuring, E

Meloni, AM

deJong, B

vanKessel, AG

机构：

[1] UNIV NIJMEGEN HOSP,DEPT HUMAN GENET,NL-6500 HB NIJMEGEN,NETHERLANDS

[2] UNIV GRONINGEN,DEPT MED GENET,NL-9700 AB GRONINGEN,NETHERLANDS

[3] UNIV LEIDEN HOSP,DEPT PATHOL,NL-2300 RC LEIDEN,NETHERLANDS

[4] GENZYME GENET,SCOTTSDALE,AZ

[5] SW BIOMED RES INST,SCOTTSDALE,AZ

来源：

CANCER GENETICS AND CYTOGENETICS | 1997年 / 96卷 / 02期

关键词：

D O I：

10.1016/S0165-4608(96)00250-6

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Recent cytogenetic analysis of a series of human renal oncocytomas revealed the presence of a recurring chromosomal translocation (5;11)(q35;q13) as sole anomaly in a subset of the tumors. The molecular characterization of this translocation was initiated using two primary t(5;11)-positive renal oncocytomas and a panel of somatic cell hybrids derived from one of these tumors, in conjunction with fluorescence in situ hybridization (FISH) and Southern blot analysis. The breakpoint in chromosome band 11q13 could be located within a genomic interval of at maximum 400 Kb immediately centromeric to the BCL1 locus. (C) Elsevier Science Inc., 1997.

引用

页码：95 / 101

页数：7

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