Cascade reactions in total synthesis

被引：1916

作者：

Nicolaou, K. C.

Edmonds, David J.

Bulger, Paul G.

机构：

[1] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA

[2] Scripps Res Inst, Skaggs Inst Chem Biol, La Jolla, CA 92037 USA

[3] Univ Calif San Diego, Dept Chem & Biochem, La Jolla, CA 92093 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2006年 / 45卷 / 43期

关键词：

cascade reactions; domino reactions; natural products; tandem reactions; total synthesis;

D O I：

10.1002/anie.200601872

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The design and implementation of cascade reactions is a challenging facet of organic chemistry, yet one that can impart striking novelty, elegance, and efficiency to synthetic strategies. The application of cascade reactions to natural products synthesis represents a particularly demanding task, but the results can be both stunning and instructive. This Review highlights selected examples of cascade reactions in total synthesis, with particular emphasis on recent applications therein. The examples discussed herein illustrate the power of these processes in the construction of complex molecules and underscore their future potential in chemical synthesis. © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：7134 / 7186

页数：53

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