Cediranib: profile of a novel anti-angiogenic agent in patients with glioblastoma

被引：50

作者：

Dietrich, Joerg ^{[1
]}

Wang, Daphne ^{[1
]}

Batchelor, Tracy T. ^{[1
]}

机构：

[1] Massachusetts Gen Hosp, Ctr Canc, Stephen E & Catherine Pappas Ctr Neurooncol, Boston, MA 02114 USA

来源：

EXPERT OPINION ON INVESTIGATIONAL DRUGS | 2009年 / 18卷 / 10期

关键词：

adverse effects; angiogenesis; AZD2171; brain tumors; cediranib; cerebral edema; glioblastoma; invasion; malignant glioma; stem cells; ENDOTHELIAL GROWTH-FACTOR; TYROSINE KINASE INHIBITOR; BEVACIZUMAB PLUS IRINOTECAN; FACTOR SIGNALING INHIBITOR; FACTOR RECEPTOR; TUMOR ANGIOGENESIS; PHASE-II; PROLONGS SURVIVAL; CLINICAL TOXICITY; VEGF INHIBITORS;

D O I：

10.1517/13543780903183528

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Background: Treatment strategies targeting angiogenesis have revealed promising results in preclinical studies and early clinical trials in patients with glioblastomas. Objective: This review evaluates the preclinical and clinical data for cediranib (AZD2171), a potent oral inhibitor of the VEGF receptor tyrosine kinase. Methods: We summarize both preclinical and clinical data for cediranib, with a focus on the treatment of glioblastomas. Results/conclusion: Cediranib is an effective drug in patients with glioblastoma, acting through inhibition of angiogenesis and normalization of tumor vasculature. Reduction of vasogenic brain edema is a key component of its treatment effect in this patient population. The primary side effects of cediranib include fatigue, diarrhea and hypertension.

引用

页码：1549 / 1557

页数：9

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