Vaccines: the Fourth Century

被引：170

作者：

Plotkin, Stanley A. ^{[1
]}

机构：

[1] Univ Penn, Doylestown, PA 18902 USA

来源：

CLINICAL AND VACCINE IMMUNOLOGY | 2009年 / 16卷 / 12期

关键词：

RESPIRATORY SYNCYTIAL VIRUS; T-CELL RESPONSES; RANDOMIZED CONTROLLED-TRIAL; SEROGROUP-B MENINGOCOCCUS; SYNONYMOUS CODON USAGE; INFLUENZA VACCINE; JAPANESE ENCEPHALITIS; RHESUS MACAQUES; DNA VACCINE; CYTOMEGALOVIRUS INFECTIONS;

D O I：

10.1128/CVI.00290-09

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Vaccine development, which began with Edward Jenner's observations in the late 18th century, has entered its 4th century. From its beginnings, with the use of whole organisms that had been weakened or inactivated, to the modern-day use of genetic engineering, it has taken advantage of the tools discovered in other branches of microbiology. Numerous successful vaccines are in use, but the list of diseases for which vaccines do not exist is long. However, the multiplicity of strategies now available, discussed in this article, portends even more successful development of vaccines.

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页码：1709 / 1719

页数：11

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