Libraries of angiotensin converting enzyme inhibitors: Solid-phase synthesis and affinity selection

被引：13

作者：

Blackburn, C

Pingali, A

Kehoe, T

Herman, LW

Wang, HQ

Kates, SA

机构：

[1] PerSeptive Biosystems, Inc., Framingham, MA 01701

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1997年 / 7卷 / 07期

关键词：

D O I：

10.1016/S0960-894X(97)00112-1

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Libraries of ACE inhibitors were prepared by solid-phase methods involving reductive alkylation of resin-bound dipeptides, H-X-Pro-DHPP-PEG-PS or H-X-X-PAL-PEG-PS. Affinity selection of the library components identified hydrophilic N-alkylated dipeptides as potential inhibitors. (C) 1997 Elsevier Science Ltd.

引用

页码：823 / 826

页数：4

共 33 条

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