Role of endogenous retroviruses in autoimmune diseases

被引：22

作者：

Colmegna, Ines

Garry, Robert F.

机构：

[1] Tulane Univ, Hlth Sci Ctr, Dept Microbiol & Immunol, New Orleans, LA 70112 USA

[2] Louisiana State Univ, Hlth Sci Ctr, Rheumatol Sect, Dept Med, New Orleans, LA 70112 USA

来源：

INFECTIOUS DISEASE CLINICS OF NORTH AMERICA | 2006年 / 20卷 / 04期

关键词：

D O I：

10.1016/j.idc.2006.09.008

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The human genome sequencing project and similar initiatives for other species have revealed that a large portion of vertebrate genomic DNA consists of genetic elements that are present in multiple copies. Human endogenous retroviruses (HERVs) represent a class of interspersed mobile repetitive elements known as retrotransposons. HERVs are closely related to certain members of the Retroviridae, an important family of human and animal viruses that includes HIV and human T-lymphotropic virus, causes of AIDS and adult T-cell leukemia, respectively. Recent studies have implicated HERVs in a wide variety of pathologic and physiologic processes. This article discusses studies that implicate HERVs in many human autoimmune diseases.

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页码：913 / +

页数：18

相关论文

共 71 条

[1] Endogenous retroviruses in systemic lupus erythematosus: Candidate lupus viruses [J].

Adelman, MK ;

Marchalonis, JJ .

CLINICAL IMMUNOLOGY, 2002, 102 (02) :107-116

[2] Human endogenous retrovirus glycoprotein-mediated induction of redox reactants causes oligodendrocyte death and demyelination [J].

Antony, JM ;

van Marle, G ;

Opii, W ;

Butterfield, DA ;

Mallet, F ;

Yong, VW ;

Wallace, JL ;

Deacon, RM ;

Warren, K ;

Power, C .

NATURE NEUROSCIENCE, 2004, 7 (10) :1088-1095

[3] Selective antibody reactivity with peptides from human endogenous retroviruses and nonviral poly(amino acids) in patients with systemic lupus erythematosus [J].

Bengtsson, A ;

Blomberg, J ;

Nived, O ;

Pipkorn, R ;

Toth, L ;

Sturfelt, G .

ARTHRITIS AND RHEUMATISM, 1996, 39 (10) :1654-1663

[4] Differential expression of a human endogenous retrovirus E transmembrane envelope glycoprotein in normal, psoriatic and atopic dermatitis human skin [J].

Bessis, D ;

Molès, JP ;

Basset-Séguin, N ;

Tesniere, A ;

Arpin, C ;

Guilhou, JJ .

BRITISH JOURNAL OF DERMATOLOGY, 2004, 151 (04) :737-745

[5] INCREASED ANTIRETROVIRAL ANTIBODY REACTIVITY IN SERA FROM A DEFINED POPULATION OF PATIENTS WITH SYSTEMIC LUPUS-ERYTHEMATOSUS - CORRELATION WITH AUTOANTIBODIES AND CLINICAL MANIFESTATIONS [J].

BLOMBERG, J ;

NIVED, O ;

PIPKORN, R ;

BENGTSSON, A ;

ERLINGE, D ;

STURFELT, G .

ARTHRITIS AND RHEUMATISM, 1994, 37 (01) :57-66

[6] Simultaneous presence of endogenous retrovirus and herpes virus antigens has profound effect on cell-mediated immune responses: Implications for multiple sclerosis [J].

Brudek, T ;

Christensen, T ;

Hansen, HJ ;

Bobecka, J ;

Moller-Larsen, A .

AIDS RESEARCH AND HUMAN RETROVIRUSES, 2004, 20 (04) :415-423

[7] Molecular characterization of HERV-H variants associated with multiple sclerosis [J].

Christensen, T ;

Sorensen, PD ;

Riemann, H ;

Hansen, HJ ;

Munch, M ;

Haahr, S ;

Moller-Larsen, A .

ACTA NEUROLOGICA SCANDINAVICA, 2000, 101 (04) :229-238

[8] Association of human endogenous retroviruses with multiple sclerosis and possible interactions with herpes viruses [J].

Christensen, T .

REVIEWS IN MEDICAL VIROLOGY, 2005, 15 (03) :179-211

[9] THE DEFECT IN FAS MESSENGER-RNA EXPRESSION IN MRL LPR MICE IS ASSOCIATED WITH INSERTION OF THE RETROTRANSPOSON, ETN [J].

CHU, JL ;

DRAPPA, J ;

PARNASSA, A ;

ELKON, KB .

JOURNAL OF EXPERIMENTAL MEDICINE, 1993, 178 (02) :723-730

[10] EVIDENCE FOR SUPERANTIGEN INVOLVEMENT IN INSULIN-DEPENDENT DIABETES-MELLITUS ETIOLOGY [J].

CONRAD, B ;

WEIDMANN, E ;

TRUCCO, G ;

RUDERT, WA ;

BEHBOO, R ;

RICORDI, C ;

RODRIQUEZRILO, H ;

FINEGOLD, D ;

TRUCCO, M .

NATURE, 1994, 371 (6495) :351-355

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