Role of endogenous retroviruses in autoimmune diseases

被引：22

作者：

Colmegna, Ines

Garry, Robert F.

机构：

[1] Tulane Univ, Hlth Sci Ctr, Dept Microbiol & Immunol, New Orleans, LA 70112 USA

[2] Louisiana State Univ, Hlth Sci Ctr, Rheumatol Sect, Dept Med, New Orleans, LA 70112 USA

来源：

INFECTIOUS DISEASE CLINICS OF NORTH AMERICA | 2006年 / 20卷 / 04期

关键词：

D O I：

10.1016/j.idc.2006.09.008

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The human genome sequencing project and similar initiatives for other species have revealed that a large portion of vertebrate genomic DNA consists of genetic elements that are present in multiple copies. Human endogenous retroviruses (HERVs) represent a class of interspersed mobile repetitive elements known as retrotransposons. HERVs are closely related to certain members of the Retroviridae, an important family of human and animal viruses that includes HIV and human T-lymphotropic virus, causes of AIDS and adult T-cell leukemia, respectively. Recent studies have implicated HERVs in a wide variety of pathologic and physiologic processes. This article discusses studies that implicate HERVs in many human autoimmune diseases.

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页码：913 / +

页数：18

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