P53 modulation of the DNA damage response

被引：211

作者：

Helton, E. Scott ^{[1
]}

Chen, Xinbin ^{[1
]}

机构：

[1] Univ Alabama Birmingham, Dept Cell Biol, Birmingham, AL 35294 USA

来源：

JOURNAL OF CELLULAR BIOCHEMISTRY | 2007年 / 100卷 / 04期

关键词：

p53; DNA damage response; DNA repair; pro-survival; cell cycle;

D O I：

10.1002/jcb.21091

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The tumor Suppressor p53 plays a central role in the DNA damage response. After exposure to genotoxic stress, p53 can both positively and negatively regulate cell fate. Initially, p53 promotes cell Survival by inducing cell cycle arrest, DNA repair, and other pro-survival pathways. However, when cells accumulate DNA damage or demonstrate aberrant growth, p53 can direct the elimination of damaged cells. In this review, we will discuss the transcriptional-dependent and -independent roles of p53 in regulating the DNA damage response.

引用

页码：883 / 896

页数：14

共 100 条

[1] Role of p53 in sensing oxidative DNA damage in response to reactive oxygen species-generating agents [J].

Achanta, G ;

Huang, P .

CANCER RESEARCH, 2004, 64 (17) :6233-6239

[2] p53 and DNA damage-inducible expression of the xeroderma pigmentosum group C gene [J].

Adimoolam, S ;

Ford, JM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (20) :12985-12990

[3] P53 modulates homologous recombination by transcriptional regulation of the RAD51 gene [J].

Arias-Lopez, C ;

Lazaro-Trueba, I ;

Kerr, P ;

Lord, CJ ;

Dexter, T ;

Iravani, M ;

Ashworth, A ;

Silva, A .

EMBO REPORTS, 2006, 7 (02) :219-224

[4] Probing p53 biological functions through the use of genetically engineered mouse models [J].

Attardi, LD ;

Donehower, LA .

MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, 2005, 576 (1-2) :4-21

[5]

Bishop AJR, 2003, CANCER RES, V63, P5335

[6] Chromosome instability is a predominant trait of fibroblasts from Li-Fraumeni families [J].

Boyle, JM ;

Mitchell, ELD ;

Greaves, MJ ;

Roberts, SA ;

Tricker, K ;

Burt, E ;

Varley, JM ;

Birch, JM ;

Scott, D .

BRITISH JOURNAL OF CANCER, 1998, 77 (12) :2181-2192

[7] p53 ubiquitination: Mdm2 and beyond [J].

Brooks, CL ;

Gu, W .

MOLECULAR CELL, 2006, 21 (03) :307-315

[8] Regeneration of peroxiredoxins by p53-regulated sestrins, homologs of bacterial AhpD [J].

Budanov, AV ;

Sablina, AA ;

Feinstein, E ;

Koonin, EV ;

Chumakov, PM .

SCIENCE, 2004, 304 (5670) :596-600

[9]

Carrier F, 1999, MOL CELL BIOL, V19, P1673

[10] Role of p53 and p21waf1/cip1 in senescence-like terminal proliferation arrest induced in human tumor cells by chemotherapeutic drugs [J].

Chang, BD ;

Xuan, YZ ;

Broude, EV ;

Zhu, HM ;

Schott, B ;

Fang, J ;

Roninson, IB .

ONCOGENE, 1999, 18 (34) :4808-4818

← 1 2 3 4 5 6 7 8 9 10 →