Aglycon switch approach toward unnatural glycosides from natural glycoside with glycosyltransferase VinC

被引：49

作者：

Minami, A

Kakinuma, K

Eguchi, T

机构：

[1] Tokyo Inst Technol, Dept Chem & Mat Sci, Meguro Ku, Tokyo 1528551, Japan

[2] Tokyo Inst Technol, Dept Chem, Meguro Ku, Tokyo 1528551, Japan

来源：

TETRAHEDRON LETTERS | 2005年 / 46卷 / 37期

基金：

日本学术振兴会;

关键词：

vicenistatin; antibiotic; glycosyltransferase; enzymatic synthesis; glycoside;

D O I：

10.1016/j.tetlet.2005.07.083

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

New aglycon switch approach using glycosyltransferase VinC was explored to create unnatural glycosides from natural glycoside in one-pot reaction. This aglycon switch comprises from two reactions, where NDP-vicenisamine generated in situ from natural glycoside vicenistatin and NDP by the reverse reaction is transferred to the targeted additional aglycons to form unnatural vicenisaminides by the forward reaction. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：6187 / 6190

页数：4

共 12 条

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