Emergence of a pneumococcal clone with cephalosporin resistance and penicillin susceptibility

被引：18

作者：

Smith, AM

Botha, RF

Koornhof, HJ

Klugman, KP

机构：

[1] S African Inst Med Res, Dept Clin Microbiol & Infect dis, Pneumococcal Dis Res Unit, MRC,SAIMR,WITS, ZA-2000 Johannesburg, South Africa

[2] Dept Microbiol, Pretoria, South Africa

[3] Emory Univ, Dept Int Hlth, Atlanta, GA 30322 USA

[4] Emory Univ, Dept Infect Dis, Atlanta, GA 30322 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2001年 / 45卷 / 09期

关键词：

D O I：

10.1128/AAC.45.9.2648-2650.2001

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We report two South African serotype 6B pneumococcal isolates with cephalosporin resistance, yet with susceptibility to penicillin. DNA fingerprinting revealed that they were clonal in origin. pbp 2X and 1A genes showed major alterations typical of cephalosporin-resistant pneumococci. The pbp 2B gene was completely unaltered, explaining the penicillin susceptibility of the isolates.

引用

页码：2648 / 2650

页数：3

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