Practical, scalable, enantioselective synthesis of (2R,3R)-N-boc-2-amino-3-cyclohexyl-3-hydroxypropanoic acid

被引：7

作者：

Alonso, N

Santacana, F

Rafecas, L

Riera, A

机构：

[1] Parc Cientif Barcelona, Unitat Rec Sintesi Asimetr, Barcelona 08028, Spain

[2] Univ Barcelona, Dept Quim Organ, E-08028 Barcelona, Spain

[3] Enantia, SL Parc Cient Barcelona, E-08028 Barcelona, Spain

来源：

ORGANIC PROCESS RESEARCH & DEVELOPMENT | 2005年 / 9卷 / 05期

关键词：

D O I：

10.1021/op0500761

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

An enantioselective synthesis of (2R,3R)-2-(tert-butoxycarbonyl)amino-3-cyclohexyl-3-hydroxypropanoic acid has been described starting from enantiomerically enriched ethyl 3-cyclohexyl-2,3-dihydroxypropanoate, easily available by Sharpless asymmetric dihydroxylation. The key reaction is the direct preparation of a sulfate by diol treatment with sulfuryl chloride, thus avoiding ruthenium-catalyzed sulfite oxidation.

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页码：690 / 693

页数：4

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