Assessment of reproducibility of creatinine measurement and MELD scoring in four liver transplant units in the UK

被引:16
作者
Goulding, Carol [1 ]
Cholongitas, Evangelous [1 ]
Nair, Devi [1 ]
Kerry, Andrew [1 ]
Patch, David [1 ]
Akyol, Murat [2 ]
Walker, Simon [2 ]
Manas, Derek [3 ]
Mc Clure, David [3 ]
Smith, Liesl [3 ]
Jamieson, Neville [4 ]
Oberg, Ingela [4 ]
Cartwright, David [4 ]
Burroughs, Andrew K. [1 ]
机构
[1] Royal Free Hosp, Liver Unit, London NW3 2QG, England
[2] Royal Infirm Edinburgh NHS Trust, Liver Unit, Edinburgh, Midlothian, Scotland
[3] Newcastle Upon Tyne NHS Hosp Trust, Liver Unit, Newcastle Upon Tyne, Tyne & Wear, England
[4] Addenbrookes Hosp, Liver Unit, Cambridge, England
关键词
creatinine; liver transplant; MELD score; organ allocation; INTERNATIONAL NORMALIZED RATIO; DISEASE MELD; SERUM CREATININE; RENAL-FUNCTION; MODEL; ALLOCATION; SURVIVAL; SELECTION; CIRRHOSIS; SCORES;
D O I
10.1093/ndt/gfp556
中图分类号
R3 [基础医学]; R4 [临床医学];
学科分类号
1001 ; 1002 ; 100602 ;
摘要
Methods. All transplant units were invited to participate; four agreed to do so, contributing 36 patients awaiting liver transplantation. Blood was collected from these 36 and divided into aliquots then sent to the four participating centres. Every centre measured creatinine and bilirubin for every patient. The results were analysed for the degree of agreement between centres for creatinine and MELD scores using the Bland-Altman method and Wilcoxon rank test. Results. The mean creatinine value varied from 101 mu mol/l in centre C to 110 mu mol/l for the same sample in centre A, with significant differences between the four centres (P < 0.05, Wilcoxon signed-rank test). The MELD scores were significantly different between centre C and all other centres (P < 0.05). Conclusion. This study demonstrates lack of agreement in measurement of serum creatinine and MELD scoring between four UK transplant centres. A difference in two MELD points can have a significant impact on patient outcome, and these factors will have to be addressed if a UK-wide transplant list is to be initiated.
引用
收藏
页码:960 / 966
页数:7
相关论文
共 25 条
[1]   A modified international normalized ratio as an effective way of prothrombin time standardization in hepatology [J].
Bellest, Laurent ;
Eschwege, Valerie ;
Poupon, Raoul ;
Chazouilleres, Olivier ;
Robert, Annie .
HEPATOLOGY, 2007, 46 (02) :528-534
[2]   STATISTICAL METHODS FOR ASSESSING AGREEMENT BETWEEN TWO METHODS OF CLINICAL MEASUREMENT [J].
BLAND, JM ;
ALTMAN, DG .
LANCET, 1986, 1 (8476) :307-310
[3]   The survival impact of liver transplantation in the MELD era, and the future for organ allocation and distribution [J].
Brown, RS ;
Lake, JR .
AMERICAN JOURNAL OF TRANSPLANTATION, 2005, 5 (02) :203-204
[4]   Review article: renal function assessment in cirrhosis - difficulties and alternative measurements [J].
Cholongitas, E. ;
Shusang, V. ;
Marelli, L. ;
Nair, D. ;
Thomas, M. ;
Patch, D. ;
Burns, A. ;
Sweny, P. ;
Burroughs, A. K. .
ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 2007, 26 (07) :969-978
[5]   Female liver transplant recipients with the same GFR as male recipients have lower MELD scores - A systematic bias [J].
Cholongitas, E. ;
Marelli, L. ;
Kerry, A. ;
Goodier, D. W. ;
Nair, D. ;
Thomas, M. ;
Patch, D. ;
Burroughs, A. K. .
AMERICAN JOURNAL OF TRANSPLANTATION, 2007, 7 (03) :685-692
[6]   Different methods of creatinine measurement significantly affect MELD scores [J].
Cholongitas, Evangelos ;
Marelli, Laura ;
Kerry, Andrew ;
Senzolo, Marco ;
Goodier, David W. ;
Nair, Devaki ;
Thomas, Michael ;
Patch, David ;
Burroughs, Andrew K. .
LIVER TRANSPLANTATION, 2007, 13 (04) :523-529
[7]   A systematic review of the performance of the Model for End-Stage Liver Disease (MELD) in the setting of liver transplantation [J].
Cholongitas, Evangelos ;
Marelli, Laura ;
Shusang, Vibhakorn ;
Senzolo, Marco ;
Rolles, Keith ;
Patch, David ;
Burroughs, Andrew K. .
LIVER TRANSPLANTATION, 2006, 12 (07) :1049-1061
[8]   Model for end-stage liver disease score-based allocation of donors for liver transplantation:: A Spanish multicenter experience [J].
de la Mata, Manuel ;
Cuende, Natividad ;
Huet, Jesus ;
Bernardos, Angel ;
Ferron, Jose Antonio ;
Santoyo, Julio ;
Pascasio, Juan Manuel ;
Rodrigo, Juan ;
Solorzano, Guillermo ;
Martin-Vivaldi, Rafael ;
Alonso, Manuel .
TRANSPLANTATION, 2006, 82 (11) :1429-1435
[9]   Impact of acute renal failure on mortality in end-stage liver disease with or without transplantation [J].
Fraley, DS ;
Burr, R ;
Bernardini, J ;
Angus, D ;
Kramer, DJ ;
Johnson, JP .
KIDNEY INTERNATIONAL, 1998, 54 (02) :518-524
[10]   Results of the first year of the new liver allocation plan [J].
Freeman, RB ;
Wiesner, RH ;
Edwards, E ;
Harper, A ;
Merion, R ;
Wolfe, R .
LIVER TRANSPLANTATION, 2004, 10 (01) :7-15