Four new cytotoxic oligosaccharidic derivatives of 12-oleanene from Lysimachia heterogenea Klatt

被引：13

作者：

Huang, Xin-an ^{[1
]}

Liang, Yong-ju ^{[2
]}

Cai, Xiao-ling ^{[3
]}

Feng, Xiao-quan ^{[1
]}

Zhang, Chuan-hai ^{[4
]}

Fu, Li-wu ^{[2
]}

Deng, Wen-di ^{[1
]}

机构：

[1] Guangzhou Univ Chinese Med, Inst Trop Med, Guangzhou 510405, Guangdong, Peoples R China

[2] Sun Yat Sen Univ, Ctr Canc, State Key Lab Oncol S China, Guangzhou 510060, Guangdong, Peoples R China

[3] Sun Yat Sen Univ, Sch Chem & Chem Engn, Guangzhou 510275, Guangdong, Peoples R China

[4] W Anhui Univ, Dept Biol & Chem, Lu An 237012, Peoples R China

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2009年 / 19卷 / 23期

基金：

中国国家自然科学基金;

关键词：

Lysimachia heterogenea Klatt; Cytotoxicity; Oligosaccharidic derivatives of 12-oleanene-3,16,23,28-tetrol; TRITERPENOID SAPONINS;

D O I：

10.1016/j.bmcl.2009.10.056

中图分类号：

R914 [药物化学];

学科分类号：

100705 [微生物与生化药学];

摘要：

Cytotoxicity-guided phytochemical analysis on the extract of Lysimachia heterogenea Klatt led to the isolation of 3 beta,16 beta-12-oleanene-3,16,23,28-tetrol (1) and its four new oligosaccharidic derivatives heterogenosides A, B, C, and D (2-5). Their structural elucidation was mainly based on NMR and mass spectral data. The time course experimental results indicated that unlike the likely lysis activity of heterogenosides B-D, heterogenoside A showed a significantly time-dependent cytotoxicity. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：6515 / 6518

页数：4

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