Brain Metabolism Correlates of The Free and Cued Selective Reminding Test in Mild Cognitive Impairment

被引：9

作者：

Caffarra, Paolo ^{[1
,2
,5
]}

Ghetti, Caterina ^{[3
]}

Ruffini, Livia ^{[4
]}

Spallazzi, Marco ^{[2
]}

Spotti, Annamaria ^{[1
]}

Barocco, Federica ^{[2
]}

Guzzo, Caterina ^{[1
]}

Marchi, Massimo ^{[1
]}

Gardini, Simona ^{[1
]}

机构：

[1] Univ Parma, Dept Neurosci, Via Gramsci 14, I-43126 Parma, Italy

[2] Azienda Osped Univ, Dipartimento Emergenza Urgenza & Area Med Gen & S, Parma, Italy

[3] Azienda Osped Univ, Dept Med Phys, Parma, Italy

[4] Azienda Osped Univ, Dept Nucl Med, Parma, Italy

[5] AUSL, CDCD, Parma, Italy

来源：

JOURNAL OF ALZHEIMERS DISEASE | 2016年 / 51卷 / 01期

关键词：

Alzheimer's disease; FDG-PET; Free and Cued Selective Reminding Test; medial-temporal structures; mild cognitive impairment; RETRIEVAL; NETWORK; CORTEX;

D O I：

10.3233/JAD-150418

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Free and Cued Selective Reminding Test (FCSRT) measures immediate and delayed episodic memory and cueing sensitivity and is suitable to detect prodromal Alzheimer's disease (AD). The present study aimed at investigating the segregation effect of FCSRT scores on brain metabolism of memory-related structures, usually affected by AD pathology, in the mild cognitive impairment (MCI) stage. A cohort of forty-eight MCI patients underwent FCSRT and F-18-FDG-PET. Multiple regression analysis showed that Immediate Free Recall correlated with brain metabolism in the bilateral anterior cingulate and delayed free recall with the left anterior cingulate and medial frontal gyrus, whereas semantic cueing sensitivity with the left posterior cingulate. FCSRT in MCI is associated with neuro-functional activity of specific regions of memory-related structures connected to hippocampal formation, such as the cingulate cortex, usually damaged in AD.

引用

页码：27 / 31

页数：5

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