Utility of a short-term 25% carbohydrate diet on improving glycemic control in type 2 diabetes mellitus

被引:26
作者
Gutierrez, M [1 ]
Akhavan, M [1 ]
Jovanovic, L [1 ]
Peterson, CM [1 ]
机构
[1] Sansum Med Res Fdn, Santa Barbara, CA 93105 USA
关键词
type 2 diabetes mellitus; carbohydrate; hemoglobin A(1c); glycemia; diet;
D O I
10.1080/07315724.1998.10718808
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Objective: To determine if introduction of a low carbohydrate diet might be a useful option for type 2 diabetic patients who do not achieve glucose target levels despite conventional treatment. Methods: Subjects with type 2 diabetes, either treated with diet alone (n=9) or second generation sulfonylurea agents (n=19), which were discontinued, were placed on a diet based on ideal body weight and comprised of 25% carbohydrate. After a mean of 8 weeks, they were then switched to a caloricly equivalent diet, but composed of 55% carbohydrate. Results: Compared to baseline diet, after 8 weeks of a 25% diet, subjects showed significantly improved glycemia as evidenced by fasting blood glucose values (p<0.005) and hemoglobin A,, levels (p<0.05). Those previously treated with oral hypoglycemic agents showed, in addition, a significant decrease in weight and diastolic blood pressure despite the discontinuation of the oral agent. When then placed on a 55% carbohydrate diet, the hemoglobin A,, rose significantly over the ensuing next 12 weeks (p<0.05). Conclusion: A low carbohydrate, caloricly-restricted diet has beneficial short-term effects in subjects with type 2 who have failed either diet or sulfonylurea therapy and may obviate the necessity for insulin. Our study also affirms the need for reassessing the role of diet whenever type 2 diabetic patients manifests hyperglycemia, despite conventional oral treatment or diet management.
引用
收藏
页码:595 / 600
页数:6
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