Different effects of the Ca2+-binding protein, KChIP1, on two Kv4 subfamily members, Kv4.1 and Kv4.2

被引：31

作者：

Nakamura, TY ^{[1
]}

Nandi, S ^{[1
]}

Pountney, DJ ^{[1
]}

Artman, M ^{[1
]}

Rudy, B ^{[1
]}

Coetzee, WA ^{[1
]}

机构：

[1] NYU, Sch Med, New York, NY 10016 USA

来源：

FEBS LETTERS | 2001年 / 499卷 / 03期

关键词：

Kv4-subunit; K+ channel-interacting protein 1; regulatory subunit; molecular diversity; potassium channel;

D O I：

10.1016/S0014-5793(01)02560-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The Ca2+-binding protein, K+ channel-interacting protein 1 (KChIP1), modulates Kv4 channels. We show here that KChIP1 affects Kv4.1 and Kv4.2 currents differently. KChIP1 slows Kv4.2 inactivation but accelerates the Kv4.1 inactivation time course. Kv4.2 activation is shifted in a hyperpolarizing direction, whereas a depolarizing shift occurs for Kv4,1, On the other hand, KChIP1 increases the current amplitudes and accelerates recovery from inactivation of both currents, An involvement of the Kv4 N-terminus in these differential effects is demonstrated using chimeras of Kv4.2 and Kv4.1, These results reveal a no, el interaction of KChIP1 with these two Kv4 members. This represents a mechanism to further increase the functional diversity of K+ channels. (C) 2001 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.

引用

页码：205 / 209

页数：5

共 27 条

[1] Modulation of A-type potassium channels by a family of calcium sensors [J].