New rearranged products from the methylation of 13-oxobaccatin III

被引:6
作者
Pinciroli, V
Ceccarelli, W
FusarBassini, D
Menichincheri, M
Mongelli, N
Vanotti, E
机构
[1] Pharmacia and Upjohn, R and D, 20014 Nerviano (MI)
关键词
D O I
10.1016/S0040-4039(97)82965-6
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Treatment of 7-triethylsilyl-13-oxobaccatin III (1) with sodium hydride and methyl iodide gave the methylated ten-membered ring compound 2 that rearranged, via intramolecular aldol condensation, to unsaturated decalin ring system (3, 4, 5). These molecules were characterized by 1D and 2D NMR tecniques. Copyright (C) 1996 Elsevier Science Ltd
引用
收藏
页码:9365 / 9368
页数:4
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