De novo synthesis of artificial ribonucleases with benign metal catalysts

被引:35
作者
Putnam, WC [1 ]
Bashkin, JK [1 ]
机构
[1] Washington Univ, Dept Chem, St Louis, MO 63130 USA
关键词
D O I
10.1039/a908783d
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
A zinc(II)-neocuproine based ribozyme mimic has been constructed for the sequence-selective transesterification of RNA using a begin metal catalyst.
引用
收藏
页码:767 / 768
页数:2
相关论文
共 15 条
[1]  
Bashkin JK, 1996, NATO ADV SCI INST SE, V479, P355
[2]  
Bernini I., 1994, BIOINORGANIC CHEM
[3]  
CECH TR, 1988, JAMA-J AM MED ASSOC, V260, P3030
[4]  
COHEN JS, 1989, OLIGODEOXYNUCLEOTIDE
[5]   Precise control of RNA cleavage by ribozyme mimics [J].
Daniher, AT ;
Bashkin, JK .
CHEMICAL COMMUNICATIONS, 1998, (10) :1077-1078
[6]   The sequence-specific cleavage of RNA by artificial chemical ribonucleases [J].
Haner, R ;
Hall, J .
ANTISENSE & NUCLEIC ACID DRUG DEVELOPMENT, 1997, 7 (04) :423-430
[7]   IMIDAZOLE TETHERED OLIGODEOXYRIBONUCLEOTIDES - SYNTHESIS AND RNA CLEAVING ACTIVITY [J].
HOVINEN, J ;
GUZAEV, A ;
AZHAYEVA, E ;
AZHAYEV, A ;
LONNBERG, H .
JOURNAL OF ORGANIC CHEMISTRY, 1995, 60 (07) :2205-2209
[8]   RAPID HYDROLYSIS OF RNA WITH A CU-II COMPLEX [J].
LINKLETTER, B ;
CHIN, J .
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 1995, 34 (04) :472-474
[9]   Metal complex conjugates of antisense DNA which display ribozyme-like activity [J].
Magda, D ;
Wright, M ;
Crofts, S ;
Lin, A ;
Sessler, JL .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1997, 119 (29) :6947-6948
[10]   Synthesis and kinetic properties of ribozyme analogues prepared using phosphoramidite derivatives of dysprosium(III) texaphyrin [J].
Magda, D ;
Crofts, S ;
Lin, A ;
Miles, D ;
Wright, M ;
Sessler, JL .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1997, 119 (09) :2293-2294