RAPID HYDROLYSIS OF RNA WITH A CU-II COMPLEX

被引:99
作者
LINKLETTER, B [1 ]
CHIN, J [1 ]
机构
[1] MCGILL UNIV,DEPT CHEM,MONTREAL,PQ H3A 2K6,CANADA
来源
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH | 1995年 / 34卷 / 04期
关键词
BIOINORGANIC CHEMISTRY; COPPER COMPOUNDS; NUCLEIC ACIDS; RNA CLEAVAGE;
D O I
10.1002/anie.199504721
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
The methyl groups in copper complex 1 not only prevent dimerization but also activate the complex for RNA hydrolysis. The half‐life for the hydrolysis of ApA (0.5 mM) promoted by 1 is only 3 min. Thus 1 is currently the most effective transition metal complex for hydrolyzing RNA. (Figure Presented.) Copyright © 1995 by VCH Verlagsgesellschaft mbH, Germany
引用
收藏
页码:472 / 474
页数:3
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