RAPID HYDROLYSIS OF RNA WITH A CU-II COMPLEX

被引：99

作者：

LINKLETTER, B ^{[1
]}

CHIN, J ^{[1
]}

机构：

[1] MCGILL UNIV,DEPT CHEM,MONTREAL,PQ H3A 2K6,CANADA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH | 1995年 / 34卷 / 04期

关键词：

BIOINORGANIC CHEMISTRY; COPPER COMPOUNDS; NUCLEIC ACIDS; RNA CLEAVAGE;

D O I：

10.1002/anie.199504721

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The methyl groups in copper complex 1 not only prevent dimerization but also activate the complex for RNA hydrolysis. The half‐life for the hydrolysis of ApA (0.5 mM) promoted by 1 is only 3 min. Thus 1 is currently the most effective transition metal complex for hydrolyzing RNA. (Figure Presented.) Copyright © 1995 by VCH Verlagsgesellschaft mbH, Germany

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页码：472 / 474

页数：3

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