Growth signaling in breast cancer cells: outcomes and promises of proteomics

被引：17

作者：

Adriaenssens, E

Lemoine, J

El Yazidi-Belkoura, I

Hondermarck, H

机构：

[1] Univ Lille 1, Lab Biol Dev, UPRES EA 1033, F-59650 Villeneuve Dascq, France

[2] Univ Sci & Technol Lille, Chim Biol Lab, UMR 8576, CNRS, Villeneuve Dascq, France

来源：

BIOCHEMICAL PHARMACOLOGY | 2002年 / 64卷 / 5-6期

关键词：

growth factors; oncogenes; breast cancer; signaling pathways; proteomics;

D O I：

10.1016/S0006-2952(02)01141-3

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Methods in functional proteomics are now used to study the intracellular signaling pathways that underlie the development of breast cancer. As shown with fibroblast growth factor-2, the oncogenic/non-coding mRNA H19 and 14-3-3 proteins, proteomics is a powerful approach to identify signaling proteins and to decipher the complex signaling circuitry involved in growth of breast cancer cells. Together with genomics, proteomics is now providing a way to define molecular processes involved in breast cancerogenesis and to identify new therapeutic targets. (C) 2002 Elsevier Science Inc. All rights reserved.

引用

页码：797 / 803

页数：7

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