Advances in mass spectrometry for proteome analysis

被引：78

作者：

Chalmers, MJ ^{[1
]}

Gaskell, SJ ^{[1
]}

机构：

[1] Univ Manchester, Inst Sci & Technol, Dept Chem, Michael Barber Ctr Mass Spectrometry, Manchester M60 1QD, Lancs, England

来源：

CURRENT OPINION IN BIOTECHNOLOGY | 2000年 / 11卷 / 04期

关键词：

D O I：

10.1016/S0958-1669(00)00114-2

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The most demanding problems in proteomics continue to challenge modern mass spectrometry. Recent developments in instrument design have led to lower limits of detection, while new ion activation techniques and improved understanding of gas-phase ion chemistry have enhanced the capabilities of tandem mass spectrometry for peptide and protein structure elucidation. Future developments must address the understanding of protein-protein interactions and the characterisation of the dynamic proteome.

引用

页码：384 / 390

页数：7

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