Opinion - How many drug targets are there?

被引:2652
作者
Overington, John P.
Al-Lazikani, Bissan
Hopkins, Andrew L.
机构
[1] Inpharmat Ltd, London WC1A 1NU, England
[2] Pfizer Ltd, Global Res & Dev, Sandwich CT13 9NJ, Kent, England
关键词
D O I
10.1038/nrd2199
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
For the past decade, the number of molecular targets for approved drugs has been debated. Here, we reconcile apparently contradictory previous reports into a comprehensive survey, and propose a consensus number of current drug targets for all classes of approved therapeutic drugs. One striking feature is the relatively constant historical rate of target innovation ( the rate at which drugs against new targets are launched); however, the rate of developing drugs against new families is significantly lower. The recent approval of drugs that target protein kinases highlights two additional trends: an emerging realization of the importance of polypharmacology, and also the power of a gene-family-led approach in generating novel and important therapies.
引用
收藏
页码:993 / 996
页数:4
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