IDN1 and IDN2 are required for de novo DNA methylation in Arabidopsis thaliana

被引：84

作者：

Ausin, Israel ^{[1
]}

Mockler, Todd C. ^{[2
,3
]}

Chory, Joanne ^{[4
,5
]}

Jacobsen, Steven E. ^{[1
,6
]}

机构：

[1] Univ Calif Los Angeles, Dept Mol Cell & Dev Biol, Los Angeles, CA 90024 USA

[2] Oregon State Univ, Dept Bot & Plant Pathol, Corvallis, OR 97331 USA

[3] Oregon State Univ, Ctr Genome Res & Biocomp, Corvallis, OR 97331 USA

[4] Salk Inst Biol Studies, Plant Biol Lab, La Jolla, CA 92037 USA

[5] Howard Hughes Med Inst, La Jolla, CA USA

[6] Univ Calif Los Angeles, Howard Hughes Med Inst, Los Angeles, CA 90024 USA

来源：

NATURE STRUCTURAL & MOLECULAR BIOLOGY | 2009年 / 16卷 / 12期

基金：

美国国家卫生研究院;

关键词：

PROCESSING CENTER; GENES; PROTEIN; DOMAIN; PLANTS; DRM;

D O I：

10.1038/nsmb.1690

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

DNA methylation is an epigenetic mark affecting genes and transposons. Screening for mutants that fail to establish DNA methylation yielded two we termed "involved in de novo" (idn) 1 and 2. IDN1 encodes DMS3, an SMC-related protein, and IDN2 encodes a previously unknown double-stranded RNA-binding protein with homology to SGS3. IDN1 and IDN2 control de novo methylation and small interfering RNA (siRNA)-mediated maintenance methylation and are components of the RNA-directed DNA methylation pathway.

引用

页码：1325 / 1327

页数：3

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