IDH1 Mutations in Gliomas: When an Enzyme Loses Its Grip

被引：58

作者：

Frezza, Christian ^{[1
]}

Tennant, Daniel A. ^{[1
]}

Gottlieb, Eyal ^{[1
]}

机构：

[1] Beatson Inst Canc Res, Glasgow G61 1BD, Lanark, Scotland

来源：

CANCER CELL | 2010年 / 17卷 / 01期

关键词：

SUCCINATE-DEHYDROGENASE;

D O I：

10.1016/j.ccr.2009.12.031

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The growing interest in cancer metabolism is best demonstrated by the rapid progress made in studying isocitrate dehydrogenase (IDH) mutations since their discovery just over a year ago. In a recent study published in Nature, Dang et al. identified 2-hydroxyglutarate as a product of tumor-associated IDH mutants with potential oncogenic activities.

引用

页码：7 / 9

页数：3

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