Characterization of the DGAT1 gene in the New Zealand dairy population

被引：177

作者：

Spelman, RJ

Ford, CA

McElhinney, P

Gregory, GC

Snell, RG

机构：

[1] Livestock Improvement Corp, Hamilton, New Zealand

[2] ViaLactia BioSci Ltd, Auckland, New Zealand

来源：

JOURNAL OF DAIRY SCIENCE | 2002年 / 85卷 / 12期

关键词：

DGAT1; dairy cattle; quantitative trait loci;

D O I：

10.3168/jds.S0022-0302(02)74440-8

中图分类号：

S8 [畜牧、动物医学、狩猎、蚕、蜂];

学科分类号：

0905 ;

摘要：

Recently, DGAT1 was identified as the gene that underlies the QTL for bovine milk production on chromosome 14. This study investigated the effect of the. reported. polymorphism in three dairy breeds in New Zealand. Statistically significant results were identified for milk fat, milk protein, and volume for Jersey and Holstein-Friesian breeds, and only milk volume for Ayr-shires. The average allele substitution effects were 2 to 3 jig of protein and 120 to 1301 milk for both the Jersey and Holstein-Friesian breeds. For milk fat, the average allele substitution effect was 6 kg for Holstein-Friesians and. 3 kg for Jerseys. In all breeds, where the polymorphism increased milk fat yield, it decreased milk protein yield and milk volume.

引用

页码：3514 / 3517

页数：4

共 13 条

[1]

[Anonymous], INTRO QUANTITATIVE G

[2]

BOICHARD DC, 2000, 51 EAAP M HAG NETH

[3] Cloning of DGAT2, a second mammalian diacylglycerol acyltransferase, and related family members [J].

Cases, S ;

Stone, SJ ;

Zhou, P ;

Yen, E ;

Tow, B ;

Lardizabal, KD ;

Voelker, T ;

Farese, RV .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (42) :38870-38876

[4] A QTL with major effect on milk yield and composition maps to bovine Chromosome 14 [J].

Coppieters, W ;

Riquet, J ;

Arranz, JJ ;

Berzi, P ;

Cambisano, N ;

Grisart, B ;

Karim, L ;

Marcq, F ;

Moreau, L ;

Nezer, C ;

Simon, P ;

Vanmanshoven, P ;

Wagenaar, D ;

Georges, M .

MAMMALIAN GENOME, 1998, 9 (07) :540-544

[5]

FARNIR F, 2002, IN PRESS GENETICS

[6] Positional candidate cloning of a QTL in dairy cattle:: Identification of a missense mutation in the bovine DGAT1 gene with major effect on milk yield and composition [J].

Grisart, B ;

Coppieters, W ;

Farnir, F ;

Karim, L ;

Ford, C ;

Berzi, P ;

Cambisano, N ;

Mni, M ;

Reid, S ;

Simon, P ;

Spelman, R ;

Georges, M ;

Snell, R .

GENOME RESEARCH, 2002, 12 (02) :222-231

[7] A genome scan for QTL influencing milk production and health traits in dairy cattle [J].

Heyen, DW ;

Weller, JI ;

Ron, M ;

Band, M ;

Beever, JE ;

Feldmesser, E ;

Da, Y ;

Wiggans, GR ;

VanRaden, PM ;

Lewin, HA .

PHYSIOLOGICAL GENOMICS, 1999, 1 (03) :165-175

[8] RESTRICTED MAXIMUM-LIKELIHOOD-ESTIMATION OF VARIANCE-COMPONENTS FOR UNIVARIATE ANIMAL-MODELS USING SPARSE-MATRIX TECHNIQUES AND AVERAGE INFORMATION [J].

JOHNSON, DL ;

THOMPSON, R .

JOURNAL OF DAIRY SCIENCE, 1995, 78 (02) :449-456

[9] A mammary gland EST showing linkage disequilibrium to a milk production QTL on bovine Chromosome 14 [J].

Looft, C ;

Reinsch, N ;

Karall-Albrecht, C ;

Paul, S ;

Brink, M ;

Thomsen, H ;

Brockmann, G ;

Kühn, C ;

Schwerin, M ;

Kalm, E .

MAMMALIAN GENOME, 2001, 12 (08) :646-650

[10] Fine-mapping of quantitative trait loci by identity by descent in outbred populations: Application to milk production in dairy cattle [J].

Riquet, J ;

Coppieters, W ;

Cambisano, N ;

Arranz, JJ ;

Berzi, P ;

Davis, SK ;

Grisart, B ;

Farnir, F ;

Karim, L ;

Mni, M ;

Simon, P ;

Taylor, JF ;

Vanmanshoven, P ;

Wagenaar, D ;

Womack, JE ;

Georges, M .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (16) :9252-9257

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