Trp64Arg mutation of beta 3-adrenergic receptor in essential hypertension - Insulin resistance and the adrenergic system

被引：37

作者：

Fujisawa, T ^{[1
]}

Ikegami, H ^{[1
]}

Yamato, E ^{[1
]}

Hamada, Y ^{[1
]}

Kamide, K ^{[1
]}

Rakugi, H ^{[1
]}

Higaki, J ^{[1
]}

Murakami, H ^{[1
]}

Shimamoto, K ^{[1
]}

Ogihara, T ^{[1
]}

机构：

[1] OSAKA UNIV,SCH MED,DEPT GERIATR MED,SUITA,OSAKA 565,JAPAN

来源：

AMERICAN JOURNAL OF HYPERTENSION | 1997年 / 10卷 / 01期

关键词：

beta-adrenergic receptor; essential hypertension; insulin resistance; missense mutation; genetic predisposition;

D O I：

10.1016/S0895-7061(96)00297-X

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

A putative pathogenic mutation in the beta 3-adrenergic receptor gene (Trp64Arg) has been reported to be associated with higher diastolic blood pressure as well as clinical features of the insulin resistance syndrome and an earlier onset of non-insulin-dependent diabetes mellitus (NIDDM) in Pima Indians and Finns. Because essential hypertension is reported to be associated with insulin resistance, we studied the mutation in Japanese patients with essential hypertension to clarify associations of this mutation with hypertension, insulin resistance, and basal adrenergic state in hypertensive subjects. The allele frequency of the mutation (Arg) in patients with essential hypertension was similar to that in control subjects (35 of 202 alleles [17.3%] v 27 of 146 [18.5%], respectively, P > .7). Insulin sensitivity measured by hyperinsulinemic euglycemic glucose clamp and plasma norepinephrine and epinephrine levels were also similar in hypertensive subjects with and without the mutation. These data suggest that Trp64Arg mutation in the beta 3-adrenergic receptor gene does not play a major role insusceptibility to essential hypertension or in insulin resistance and basal adrenergic state in hypertension. (C) 1997 American Journal of Hypertension, Ltd.

引用

页码：101 / 105

页数：5