Diet and Parkinson's disease:: A potential role of dairy products in men

被引:103
作者
Chen, HL
Zhang, SMM
Hernán, MA
Willett, WC
Ascherio, A
机构
[1] Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA
[2] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA
[3] Brigham & Womens Hosp, Div Prevent Med, Boston, MA 02115 USA
[4] Brigham & Womens Hosp, Channing Lab, Dept Med, Boston, MA 02115 USA
[5] Harvard Univ, Sch Med, Boston, MA USA
关键词
D O I
10.1002/ana.10381
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Diet may play a causative role in Parkinson's disease (PD), but potential associations between diet and PD risk rarely have been assessed in prospective studies. We investigated associations between food intakes and PD risk in two large prospective cohorts in which 210 incident PD cases in men and 184 in women were documented. A positive association was found between dairy intake and PD risk in men (relative risk [RR] comparing extreme categories, 1.8; p trend = 0.004), but not in women (RR, 1.1; p trend = 0.9). No other food groups were associated with PD risk in either men or women. Further analyses among men showed significant positive associations with PD risk for intakes of several dairy foods as well as dairy calcium (RR, 1.5; p trend = 0.02), dairy vitamin D (RR, 1.6; p trend = 0.004), dairy protein (RR, 1.6; p trend = 0.01), and lactose (RR, 1.8; p trend = 0.002), but not dairy fat (RR, 1.1; p trend = 0.4). Intakes of calcium, vitamin D, and protein from other dietary or supplemental sources were not related to PD risk in men. Our results suggest that higher intake of dairy products may increase the risk of PD in men; however, this finding needs further evaluation, and the underlying active components need to be identified.
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页码:793 / 801
页数:9
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