Proline organocatalysis as a new tool for the asymmetric synthesis of ulosonic acid precursors

被引：62

作者：

Enders, Dieter ^{[1
]}

Gasperi, Tecla ^{[1
]}

机构：

[1] Rhein Westfal TH Aachen, Inst Organ Chem, D-52074 Aachen, Germany

来源：

CHEMICAL COMMUNICATIONS | 2007年 / 01期

关键词：

D O I：

10.1039/b611265j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

PEP and aldolase mimicry is the key for a direct organocatalytic entry to precursors of ulosonic acids, biomolecules of enormous importance in biology, chemistry and medicine; in the key aldol reaction the dimethylacetal of pyruvic aldehyde is used as phosphoenolpyruvate (PEP) equivalent and the amino acid proline functions as an organocatalyst, imitating the enzyme.

引用

页码：88 / 90

页数：3

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