Molecular-targeted nanotherapies in cancer: Enabling treatment specificity

被引：44

作者：

Blanco, Elvin ^{[1
]}

Hsiao, Angela ^{[1
]}

Ruiz-Esparza, Guillermo U. ^{[1
]}

Landry, Matthew G. ^{[1
]}

Meric-Bernstam, Funda ^{[2
]}

Ferrari, Mauro ^{[1
]}

机构：

[1] Methodist Hosp, Res Inst, Dept Nanomed, Houston, TX 77030 USA

[2] Univ Texas MD Anderson Canc Ctr, Dept Surg Oncol, Houston, TX 77030 USA

来源：

MOLECULAR ONCOLOGY | 2011年 / 5卷 / 06期

关键词：

Nanomedicine; Cancer; Molecular therapeutics; siRNA; Liposomes; Polymer micelles; PEGYLATED-LIPOSOMAL DOXORUBICIN; SILICON MICROPARTICLES; DRUG-DELIVERY; BREAST-CANCER; PHASE-I; BEVACIZUMAB; SIRNA; EFFICACY; MICELLES; CELLS;

D O I：

10.1016/j.molonc.2011.10.005

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Chemotherapy represents a mainstay and powerful adjuvant therapy in the treatment of cancer. The field has evolved from drugs possessing all-encompassing cell-killing effects to those with highly targeted, specific mechanisms of action; a direct byproduct of enhanced understanding of tumorigenic processes. However, advances regarding development of agents that target key molecules and dysregulated pathways have had only modest impacts on patient survival. Several biological barriers preclude adequate delivery of drugs to tumors, and remain a formidable challenge to overcome in chemotherapy. Currently, the field of nanomedicine is enabling the delivery of chemotherapeutics, including repositioned drugs and siRNAs, by giving rise to carriers that provide for protection from degradation, prolonged circulation times, and increased tumor accumulation, all the while resulting in reduced patient morbidity. This review aims to highlight several innovative, nanoparticle-based platforms with the potential of providing clinical translation of several novel chemotherapeutic agents. We will also summarize work regarding the development of a multistage drug delivery strategy, a robust carrier platform designed to overcome several biological barriers while en route to tumors. (C) 2011 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：492 / 503

页数：12

共 78 条

[1] Emerging Targeted Therapies for Breast Cancerd [J].

Alvarez, Ricardo H. ;

Valero, Vicente ;

Hortobagyi, Gabriel N. .

JOURNAL OF CLINICAL ONCOLOGY, 2010, 28 (20) :3366-3379

[2] Long-term toxic effects of adjuvant chemotherapy in breast cancer [J].

Azim, H. A., Jr. ;

de Azambuja, E. ;

Colozza, M. ;

Bines, J. ;

Piccart, M. J. .

ANNALS OF ONCOLOGY, 2011, 22 (09) :1939-1947

[3] An NQO1-and PARP-1-mediated cell death pathway induced in non-small-cell lung cancer cells by β-lapachone [J].

Bey, Erik A. ;

Bentle, Melissa S. ;

Reinicke, Kathryn E. ;

Dong, Ying ;

Yang, Chin-Rang ;

Girard, Luc ;

Minna, John D. ;

Bornmann, William G. ;

Gao, Jinming ;

Boothman, David A. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (28) :11832-11837

[4] β-Lapachone-containing PEG-PLA polymer micelles as novel nanotherapeutics against NQO1-overexpres sing tumor cells [J].

Blanco, Elvin ;

Bey, Erik A. ;

Dong, Ying ;

Weinberg, Brent D. ;

Sutton, Damon M. ;

Boothman, David A. ;

Gao, Jinming .

JOURNAL OF CONTROLLED RELEASE, 2007, 122 (03) :365-374

[5] β-Lapachone Micellar Nanotherapeutics for Non-Small Cell Lung Cancer Therapy [J].

Blanco, Elvin ;

Bey, Erik A. ;

Khemtong, Chalermchai ;

Yang, Su-Geun ;

Setti-Guthi, Jagadeesh ;

Chen, Huabing ;

Kessinger, Chase W. ;

Carnevale, Kevin A. ;

Bornmann, William G. ;

Boothman, David A. ;

Gao, Jinming .

CANCER RESEARCH, 2010, 70 (10) :3896-3904

[6] Multifunctional Micellar Nanomedicine for Cancer Therapy [J].

Blanco, Elvin ;

Kessinger, Chase W. ;

Sumer, Baran D. ;

Gao, Jinming .

EXPERIMENTAL BIOLOGY AND MEDICINE, 2009, 234 (02) :123-131

[7] Trastuzumab-Based Therapy for Patients With HER2-Positive Breast Cancer From Early Scientific Development to Foundation of Care [J].

Brufsky, Adam .

AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS, 2010, 33 (02) :186-195

[8] Cytotoxic effects of a novel pyrazolopyrimidine derivative entrapped in liposomes in anaplastic thyroid cancer cells in vitro and in xenograft tumors in vivo [J].

Celano, M. ;

Schenone, S. ;

Cosco, D. ;

Navarra, M. ;

Puxeddu, E. ;

Racanicchi, L. ;

Brullo, C. ;

Varano, E. ;

Alcaro, S. ;

Ferretti, E. ;

Botta, G. ;

Filetti, S. ;

Fresta, M. ;

Botta, M. ;

Russo, D. .

[9] Tailored Porous Silicon Microparticles: Fabrication and Properties [J].

Chiappini, Ciro ;

Tasciotti, Ennio ;

Fakhoury, Jean R. ;

Fine, Daniel ;

Pullan, Lee ;

Wang, Young-Chung ;

Fu, Lianfeng ;

Liu, Xuewu ;

Ferrari, Mauro .

CHEMPHYSCHEM, 2010, 11 (05) :1029-1035

[10] Growth-Inhibitory and Antiangiogenic Activity of the MEK Inhibitor PD0325901 in Malignant Melanoma with or without BRAF Mutations [J].

Ciuffreda, Ludovica ;

Del Bufalo, Donatella ;

Desideri, Marianna ;

Di Sanza, Cristina ;

Stoppacciaro, Antonella ;

Ricciardi, Maria Rosaria ;

Chiaretti, Sabina ;

Tavolaro, Simona ;

Benassi, Barbara ;

Bellacosa, Alfonso ;

Foa, Robin ;

Tafuri, Agostino ;

Cognetti, Francesco ;

Anichini, Andrea ;

Zupi, Gabriella ;

Milella, Michele .

NEOPLASIA, 2009, 11 (08) :720-U21

← 1 2 3 4 5 6 7 8 →