Iron-catalyzed Chemoselective Cross-coupling of α-Bromocarboxylic Acid Derivatives with Aryl Grignard Reagents

被引：38

作者：

Jin, Masayoshi ^{[1
,2
]}

Nakamura, Masaharu ^{[1
]}

机构：

[1] Kyoto Univ, IRCELS, Inst Chem Res, Kyoto 6110011, Japan

[2] Daiichi Sankyo Co Ltd, Proc Technol Res Labs, Pharmaceut Technol Div, Hiratsuka, Kanagawa 2540014, Japan

来源：

CHEMISTRY LETTERS | 2011年 / 40卷 / 09期

基金：

日本学术振兴会;

关键词：

BEARING BETA-HYDROGENS; ALKYL-HALIDES; PALLADIUM; ARYLATION; ESTERS; COMPLEX; PHOSPHINE; ACETALS; KETONES;

D O I：

10.1246/cl.2011.1012

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We have developed a simple and effective synthetic method of alpha-arylcarboxylic acid derivatives based on the iron-catalyzed cross-coupling reaction of alpha-bromocarboxylic acid derivatives with aryl Grignard reagents. The reaction proceeds smoothly at -78 degrees C in a chemoselective manner to produce the coupling product in good to excellent yields.

引用

页码：1012 / 1014

页数：3

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